Table 5.
AUROC, sensitivity and specificity for each biomarker, excluding those who had received anticoagulation
| Biomarker | AUC 95% CI | Sensitivity at predefined threshold 95% CI | Specificity at predefined threshold 95% CI | Sensitivity at threshold with optimal sensitivity 95% CI | Specificity at threshold with optimal sensitivity 95% CI |
|---|---|---|---|---|---|
| APTT |
0·581 0·244 to 0·919 |
0·00 0·000 to 0·602 |
0·967 0·885 to 0·996 |
1 0·398 to 1 |
0·217 0·121 to 0·342 |
| BNP |
0·774 0·670 to 0·878 |
0·00 0·000 to 0·602 |
0·935 0·843 to 0·982 |
1 0·398 to 1 |
0·742 0·615 to 0·845 |
| C‐Reactive protein |
0·609 0·250 to 0·968 |
1·00 0·398 to 1·000 |
0·097 0·036 to 0·199 |
1 0·398 to 1 |
0·113 0·047 to 0·219 |
| Clauss fibrinogen |
0·648 0·259 to 1·000 |
0·75 0·194 to 0·994 |
0·250 0·147 to 0·379 |
1 0·398 to 1 |
0·117 0·048 to 0·226 |
| D‐Dimer (ELISA) |
0·615 0·210 to 1·000 |
0·50 0·068 to 0·932 |
0·148 0·070 to 0·262 |
1 0·398 to 1 |
0·213 0·119 to 0·337 |
| D‐Dimer (Innovance) |
0·613 0·299 to 0·926 |
0·25 0·006 to 0·806 |
0·672 0·540 to 0·787 |
1 0·398 to 1 |
0·262 0·158 to 0·391 |
| MRproANP |
0·698 0·357 to 1·000 |
0·50 0·068 to 0·932 |
0·823 0·705 to 0·908 |
1 0·398 to 1 |
0·210 0·117 to 0·332 |
| Prothrombin fragment 1 + 2 |
0·795 0·644 to 0·947 |
0·00 0·000 to 0·602 |
0·918 0·819 to 0·973 |
1 0·398 to 1 |
0·639 0·506 to 0·758 |
| Plasmin‐antiplasmin complexes |
0·684 0·335 to 1·000 |
0·50 0·068 to 0·932 |
0·770 0·645 to 0·868 |
1 0·398 to 1 |
0·180 0·094 to 0·300 |
| Prothombin time |
0·572 0·306 to 0·838 |
0·00 0·000 to 0·602 |
0·831 0·710 to 0·916 |
1 0·398 to 1 |
0·220 0·123 to 0·347 |
| Thrombin generation (Lag time) |
0·735 0·531 to 0·940 |
1·00 0·398 to 1·000 |
0·000 0·000 to 0·060 |
1 0·398 to 1 |
0·450 0·321 to 0·584 |
| Thrombin generation (Endogenous potential) |
0·454 0·155 to 0·753 |
0·50 0·068 to 0·932 |
0·525 0·393 to 0·654 |
1 0·398 to 1 |
0·233 0·134 to 0·360 |
| Thrombin generation (Peak) |
0·462 0·229 to 0·696 |
0·00 0·000 to 0·602 |
0·852 0·738 to 0·930 |
1 0·398 to 1 |
0·317 0·203 to 0·450 |
| Thrombin generation (Time to Peak) |
0·577 0·320 to 0·834 |
1·00 0·398 to 1·000 |
0·213 0·119 to 0·337 |
1 0·398 to 1 |
0·350 0·231 to 0·484 |
| Soluble tissue factor |
0·422 0·159 to 0·686 |
0·00 0·000 to 0·602 |
0·885 0·778 to 0·953 |
1 0·398 to 1 |
0 0·286 to 0·543 |
| Troponin |
0·742 0·453 to 1·000 |
0·25 0·006 to 0·806 |
0·903 0·801 to 0·964 |
1 0·398 to 1 |
0·306 0·196 to 0·437 |
95% CI, 95% confidence interval; APTT, activated partial thromboplastin time; AUC, area under the curve; AUROC, area under the receiver operator characteristic curve; BNP, brain natriuretic peptide; ELISA, enzyme‐linked immunosorbent assay; MRproANP, mid‐regional pro‐atrial natriuretic peptide.