TABLE I. Cryptococcosis in Latin America. Epidemiological and clinical data.

Country	Number of cases	Percentage of cases									Reference
		Male	HIV+	Clinical presentation (%)	Headache	High ICP > 25 cm H20	C. gattii	Lethality
								global	HIV+	HIV-
Argentina
Buenos Aires	58	100	100	Meningitis (100)	88			21	21		Cangelosi et al. (2009)
Buenos Aires	2041	75	98	Meningitis (90)	70	79	0.3		40		Arechavala et al. (2017)
Buenos Aires	58	88	100	Meningitis (100)				19	19		Ramírez et al. (2017)
Buenos Aires Province	106	71	100	Neuro (91)				36	36		Mónaco and Antabak (2008)
Chaco (Corrientes)	26	69	69	Meningitis (96)			0				Cattana et al. (2015)
Córdoba (Córdoba)	53	66	100								Luque et al. (2017)
Brazil
Bahia	104	62	12		93			43	12		Darzé et al. (2000)
Bahia	50	70	52	Meningitis (100)	92	77 (> 20 cmH2O)		22			Mascarenhas-Batista et al. (2013)
Goiás (Goiânia)	62	74	85	Meningitis (100)	76		6	48	47	56	Hasimoto e Souza et al. (2013)
Mato Grosso do Sul (Campo Grande)	123	68	84	Neuro (84)	76		10	50	51	41	Lindenberg et al. (2008)
Mina Gerais (Uberlandia)	96	80	81	Meningitis (56)			7	73	77		Moreira et al. (2006)
Mina Gerais (Uberlandia)	41	83	85	Meningitis (75)			0	58	60	25	Aguiar et al. (2017)
Mina Gerais (Uberaba)	131	69	91	Meningitis (79)	60	53	5	51			Mora et al. (2012)
Río de Janeiro (Rio de Janeiro)	696	73	61	Meningitis (96)				52	61		Leimann and Koifman (2008)
Rio de Janeiro (Rio de Janeiro)	138	76	100	Meningitis (100)				62	62		Ramírez et al. (2017)
Rio Grande do Sul (Porto Alegre)	126	77	95	Meningitis (100)	80		5				Leal et al. (2008)
São Paulo (São Paulo)	98	78	97	Meningitis (100)	91	55		30			Vidal et al. (2012)
São Paulo (São Paulo)	29	55	0	Neuro (86)	96	76 (≥ 20 cmH2O)	64	21		21	Lomes et al. (2016)
National, children	53	53	24	Neuro (96)	85		30	41			Severo et al. (2009)
Bolivia
Cochabamba	31	83	100	Meningitis (100)	23			67	67		Castro and Córdoba (2014)
Chile
Santiago	28	93	100	Meningitis (100)				21	21		Ramírez et al. (2017)
Colombia
National 1997-2005	931	83	78	Neuro (96)	85		4				Lizarazo et al. (2007)
National 2006-2010	526	77	83	Neuro (81)	84	20	3	32			Escandón et al. (2012)
Norte de Santander (Cúcuta)	90	77	70	Meningitis (100)	90	57	22	34	49	16	Lizarazo et al. (2012)
Atlántico (Barranquilla)	41	76	78	Meningitis (66)			1				Noguera et al. (2015)
National, children	41	58	24	Meningitis (88)	78		6				Lizarazo et al. (2014a)
Costa Rica
San José	71	79	73	Neuro (73)	100		0	46	46	0	Ávila and Villalobos (2016)
Cuba
La Habana	16	82	0	Neuro (100)	81			31		31	Fernández-Concepción et al. (2003)
Ecuador
Guayaquil	82	73	100	Meningitis (100)	78						Sánchez et al. (2016)
Guatemala
Guatemala	110	73	100	Meningitis (100)	80			14	14		Romero et al. (2005)
Guatemala	60	80	100	Meningitis (100)				43	43		Mejía and del Valle (2012)
Guatemala	28	72	100	Meningitis (100)	93			21	21		Herrera et al. (2014)
Honduras
Tegucigalpa	27	59	100	Meningitis (100)				33	33		Ramírez et al. (2017)
Mexico
Ciudad de Mexico	34	85	100	Meningitis (100)				38	38		Ramírez et al. (2017)
Panama
Panama	28	61	100	Meningitis (100)	96	57 (≥ 20 cmH2O)		50	50		González et al. (2013)
Paraguay
Itauguá	13	76	62	Meningitis (100)	90			46	83	20	Sierra (2013)
Peru
Lima	47	87	100	Meningitis (100)	100	64 (≥ 20 cmH2O)	0	19	19		Dammert et al. (2008)
Lima	90	77	100	Meningitis (100)				41	41		Canessa et al. (2011)
Lima	234		100	Meningitis (100)	86			20	20		Concha-Velasco et al. (2017)
Uruguay
Montevideo	147		92				0.7				Carbia et al. (2017)
Venezuela
Caracas	110	83	83	Meningitis (97)				30	32	21	Pérez et al. (2009)

ICP: intracranial pressure; Neuro: meningitis, meningoencephalitis and cryptococcoma.