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. 2017 Dec 22;21(4):371–381. doi: 10.1093/ijnp/pyx116

Figure 5.

Figure 5.

Effect of an mechanistic target of rapamycin complex 1 (mTORC1) inhibitor on the sustained antidepressant effects of ketamine and 8-OH-DPAT in the forced swim test (FST). The drug administration schedules are illustrated in A. Vehicle A, 1 % DMSO/Ringer’s solution; vehicle B, saline; vehicle C, Ringer’s solution. Values indicate the mean±SEM. (B) n=7–8, (C) n=8, (D) n=7–8. **P<.01 compared with vehicle A-treated vehicle B (B), vehicle A-treated vehicle C (C); ##P<.01 compared with vehicle A-treated ketamine (B), vehicle A-treated 8-OH-DPAT (C).