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Proportion of participants who first experiences worsening in Concise Associated Symptom Tracking (CAST) domains during the first 6 weeks of the Combining Medications to Enhance Depression Outcomes (CO-MED) trial. Worsening is defined as an increase of ≥1.28 baseline SD at week 1, 2, 4, or 6 in the CAST domains of irritability, anxiety, insomnia, and panic.
