Figure 2.

Observed rates of remission during the Combining Medications to Enhance Depression Outcomes (CO-MED) trial based on overall and individual Concise Associated Symptom Tracking (CAST) domain-specific worsening. Remission was ascribed if, of the last 2 consecutive quick inventory of depressive symptomatology self-report scores during 12-week-long acute-phase, one was <6 and the other was <8. Worsening is defined as an increase of ≥1.28 baseline SD at week 1, 2, 4, or 6 in the CAST domains of irritability, anxiety, insomnia, and panic.