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. 2018 Apr 3;6:e4533. doi: 10.7717/peerj.4533

Figure 2. Effects of PbTx-3 on O. sinensis. voltage activated currents.

Figure 2

(A) Representative ion currents evoked in response to depolarizing voltage clamp pulses under control conditions, after 15 min treatment of bolus ASW (n = 7 cells tested) and after treatment with 1 µM PbTx-3 for 15 min showing a clear decline in both peak inward and delayed outward currents (n = 14 cells tested). (B) Detail of fast inactivating inward current evoked by voltage clamp pulse from −100 mV to −60 mV before and after 1 µM PbTx-3 perfusion. (C) Combined current-voltage plot for PbTx perfusion experiments in which average peak inward current was plotted as a function of membrane voltage in the absence (black circles) and presence of 1 µM PbTx-3 (orange circles), and peak outward current in the absence (black triangles) and presence of 1 µM PbTx-3 (orange triangles). n = 14 experiments. Standard error bars are indicated.