Table 9.

Weight Loss Associated With Use of Orlistat, Lorcaserin, Liraglutide, Topiramate/Phentermine, and Naltrexone/Bupropion

Drug/Placebo	No. of Trials	Maximal Weight Loss (kg)	Weeks to Half Maximal Weight Loss (wk)	Drop Rate (%)
Orlistat	31	−6.65	35.4	29.0
Lorcaserin	5	−5.39	19.3	40.9
Liraglutide	3	−7.68	12.7	24.3
Topiramate/phentermine	6	−15.6	29.8	34.9
Naltrexone/bupropion	6	−13.2	35.2	49.1
Placebo	51	−2.71	12.3

Maximal weight loss is the modeled maximal effect and does not contain the placebo effect.

Data are from Dong et al., 2017 (334).