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. 2018 Jan 9;11(2):179–190. doi: 10.1093/ckj/sfx143

Fig. 2.

Fig. 2.

The figure shows EM from two siblings with genetic FSGS who share the same genotype (compound heterozygous R229Q + p.R286fs in the NPHS2 gene). (A, B) Focal segmental glomerulosclerosis; 58 year old Caucasian man with normal renal function (serum creatinine 1.1 mg/dL) and NS (urine protein 4.8 g/24 h, serum albumin 3.4 g/dL). EM shows diffuse foot process effacement, involving more than 80% of capillary loops; thin black arrows point to foot process effacement. See Table 3 for clinical information (patient 3) (A, ×6000 and B, ×5000). (C, D) Focal segmental glomerulosclerosis; 47 year old Caucasian woman with normal renal function (serum creatinine 0.8 mg/dL), sub-nephrotic proteinuria (2.7 g/24 h) and normal albumin (4.0 g/dL). EM shows segmental podocyte foot processes; thin black arrows point to foot process effacement and thick black arrow points to preserved foot processes. See Table 3 for clinical information (patient 4) (C, ×2900 and D, ×4800).