Table 3.

Multiple linear regression model for eGFR slope (mL/min/1.73 m²/year)

Variable	B coefficient	95% CI B coefficient	β	P
Age, years	0.045	0.026; 0.064	0.142	<0.0001
Sex, male = 1	−0.615	−1.136; −0.094	−0.069	0.021
Study periods; early = 1, mid = 2, late = 3	0.368	0.034; 0.701	0.066	0.031
Systolic blood pressure, × cmHg	−0.225	−0.325; −0.125	−0.137	<0.0001
Proteinuria, g/g creatinine	−0.630	−0.745; −0.514	−0.333	<0.0001
Dual RAS blockade (0, 1)	−1.475	−2.424; −0.526	−0.093	0.002
MTMa (0, 1)	1.290	0.420; 2.161	0.088	0.004
Constant	−1.794	−3.723; 0.136

Not in equation: comorbidity index, diabetes mellitus, baseline eGFR, smokers, diastolic blood pressure, diuretics, ACEI or ARB treatment, β-blockers, calcium-channel blockers, antiplatelet drugs, statins.

^aMTM: discontinuation at baseline of vitamin D analogues, fibrates and/or allopurinol (only in patients with suspected allopurinol hypersensitivity).