TABLE 1.
Fold change of expression of genes for mitochondrial structure and function at 3 h after CLP
| Mice | Treatment | Gene symbol | Gene name | Function | Fold change | Regulation |
|---|---|---|---|---|---|---|
| Young | CLP+vehicle | Slc25a27 | Solute carrier family 25, member 27 | Small molecule transport | −4.7 | Down-regulated |
| Bbc3 | BCL2 binding component 3 | Proapoptosis | −3.7 | Down-regulated | ||
| Slc25a30 | Solute carrier family 25, member 30 | Small molecule transport | −3.7 | Down-regulated | ||
| Slc25a14 | Solute carrier family 25, member 14 | Small molecule transport | −3.7 | Down-regulated | ||
| Cpt2 | Carnitine palmitoyltransferase 2 | Long-chain fatty acid oxidation | −2.3 | Down-regulated | ||
| Taz | Tafazzin | Inner membrane translocation | −1.9 | Down-regulated | ||
| Tomm40l | Translocase of outer mitochondrial membrane 40 homolog-like | Outer membrane translocation | −1.8 | Down-regulated | ||
| Rhot2 | Ras homolog family member T2 | Mitochondrial localization | −1.8 | Down-regulated | ||
| Slc25a4 | Solute carrier family 25, member 4 | Small molecule transport | −1.8 | Down-regulated | ||
| Slc25a24 | Solute carrier family 25, member 24 | Small molecule transport | −1.8 | Down-regulated | ||
| Pmaip1 | Phorbol-12-myristate-13-acetate-induced protein 1 | Proapoptosis | 2.4 | Up-regulated | ||
| Sod2 | Superoxide dismutase 2 | Antioxidant | 2.9 | Up-regulated | ||
| Bcl2l1 | BCL2-like 1 | Antiapoptosis | 4.3 | Up-regulated | ||
| CLP+AICAR | Slc25a2 | Solute carrier family 25, member 2 | Small molecule transport | 1.8 | Up-regulated | |
| Bcl2l1 | BCL2-like 1 | Antiapoptosis | 2.4 | Up-regulated | ||
| Mature | CLP+vehicle | Slc25a30 | Solute carrier family 25, member 30 | Small molecule transport | −3.6 | Down-regulated |
| Slc25a27 | Solute carrier family 25, member 27 | Small molecule transport | −2.4 | Down-regulated | ||
| Bbc3 | BCL2 binding component 3 | Proapoptosis | −2.4 | Down-regulated | ||
| Sod2 | Superoxide dismutase 2 | Antioxidant | 2.2 | Up-regulated | ||
| Bcl2l1 | BCL2-like 1 | Antiapoptosis | 2.9 | Up-regulated | ||
| CLP+AICAR | Sod1 | Superoxide dismutase 1 | Antioxidant | 1.5 | Up-regulated | |
| Timm23 | Translocase of inner mitochondrial membrane 23 | Inner membrane translocation | 1.6 | Up-regulated | ||
| Hsp90aa1 | Heat shock protein 90, α, class A member 1 | Chaperone | 1.6 | Up-regulated | ||
| Timm10b | Translocase of inner mitochondrial membrane 10B | Inner membrane translocation | 1.7 | Up-regulated | ||
| Slc25a37 | Solute carrier family 25, member 37 | Small molecule transport | 1.7 | Up-regulated | ||
| Timm8a1 | Translocase of inner mitochondrial membrane 8A1 | Inner membrane translocation | 1.8 | Up-regulated | ||
| Uxt | Ubiquitously expressed transcript | Mitochondrial localization | 2.0 | Up-regulated | ||
| Sod2 | Superoxide dismutase 2 | Antioxidant | 2.1 | Up-regulated | ||
| Slc25a25 | Solute carrier family 25, member 25 | Small molecule transport | 2.9 | Up-regulated |
Data are for young and mature mice treated with vehicle or AICAR (500 mg/kg, i.p.) vs. baseline expression of age-matched control mice. The regulation threshold was set at >1.5-fold change vs. control age-matched mice. The significance threshold was set at P < 0.05