TABLE 5.

S48168 concentrations in plasma and GC muscle in the 4 wk treatment groups and in the 12 wk treatment groups

Matrix	Parameter	Unit	10 mg/kg		50 mg/kg
			Mean	CV%	Mean	CV%
4 Wk treatment by UNIBA
Plasma	Concentration	µg/ml	0.881	31	3.023	34
Skeletal muscle (GC)	Concentration	µg/g	0.151	31	0.512	48.7
	KP		0.18	28.7	0.174	27.9
12 Wk treatment by AGA
Plasma	Concentration	µg/ml	6.125	44.4	18.775	25.7
Skeletal muscle (GC)	Concentration	µg/g	0.552	40.6	1.716	32
	KP		0.093	15.3	0.094	28.6
12 Wk treatment by UNIBA
Plasma	Concentration	µg/ml	0.893	54.6	5.889	75.2
Skeletal muscle (GC)	Concentration	µg/g	0.123	45.5	1.156	42
	KP		0.139	21.7	0.259	70.3

KP, plasma partition coefficient.