Table 1.
Demographic characteristics and measurements of the healthy controls and BD patients
| Controls (N=78) |
BD patients (N=137) |
BD patients after treatment |
t / χ2 | p value (95% CI)a | t / χ2 | p value (95% CI)b | |
|---|---|---|---|---|---|---|---|
| Age (yr) | 31.0 ± 10.7 | 32.1 ± 11.6 | - | -0.690 | 0.491 (-2.0 − 4.2) | - | - |
| Gender, female (%) | 44 (56.4) | 70 (51.1) | - | 0.564 | 0.453 (-0.1 − 0.2) | - | - |
| HAMD score | 3.2 ± 1.6 | 19.4 ± 5.5 | 11.4 ± 6.9 | -25.327 | <0.001* (14.9 − 17.4) | 12.911 | <0.001* (6.8 − 9.2) |
| YMRS score | 4.1 ± 0.4 | 9.2 ± 4.0 | 6.4 ± 3.4 | -11.428 | <0.001* (4.3 − 6.0) | 8.147 | <0.001* (2.2 − 3.6) |
| FGF21 (pg/ml) | 176.0 ± 152.8 | 167.7 ± 122.0 | 207.1 ± 162.3 | 0.421 | 0.674 (-47.1 − 30.5) | -3.476 | 0.001* (-61.8 − -17.0) |
| Body weight (kg) | 64.5 ± 15.2 | 62.6 ± 14.3 | 63.5 ± 14.6 | 0.922 | 0.357 (-6.0 − 2.2) | -4.108 | <0.001* (-1.3 − -0.5) |
| BMI (kg/m2) | 23.7 ± 4.4 | 22.8 ± 4.4 | 23.2 ± 4.6 | 1.317 | 0.189 (-2.1 − 0.4) | -4.216 | <0.001* (-0.5 − -0.2) |
| Waist circumference (cm) | 79.2 ± 12.3 | 79.4 ± 12.2 | 80.3 ± 12.1 | -0.107 | 0.915 (-3.2 − 3.6) | -2.227 | 0.028* (-1.6 − -0.1) |
| Cholesterol (mg/dl) | 186.3 ± 37.2 | 183.5 ± 33.4 | 182.9 ± 34.1 | 0.573 | 0.567 (-12.6 − 6.9) | 0.302 | 0.763 (-3.2 − 4.4) |
| TG (mg/dl) | 103.2 ± 84.1 | 90.7 ± 46.9 | 94.6 ± 53.3 | 1.391 | 0.230 (-33.0 − 8.0) | -1.126 | 0.262 (-10.8 − 3.0) |
| LDL (mg/dl) | 116.4 ± 33.4 | 111.3 ± 28.5 | 111.4 ± 30.1 | 1.177 | 0.241 (-13.6 − 3.4) | -0.035 | 0.972 (-3.4 − 3.2) |
Abbreviations: YMRS, 11-item Young Mania Rating Scale; HDRS, 17-item Hamilton Depression Rating Scale; TG, triglyceride; LDL, low-density lipoprotein; BMI, body mass index.
a Compared with healthy controls; bpaired t-test in BD patients at baseline and after treatment.