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. 2018 Jan 29;46(6):2820–2833. doi: 10.1093/nar/gky028

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Label-free interactomics identifies novel telomere-binding proteins in Trypanosoma brucei. (A) Experiment design and volcano plot showing how telomeric DNA-binding proteins were identified. Quadruplicates of procyclic cell extracts were incubated either with telomeric TTAGGG-repeat or control TGTGAG-repeat oligonucleotides. Seventeen proteins were significantly enriched with telomeric DNA compared to control oligonucleotides. (B) Experiment design of the TbTRF Co-IP and resulting volcano plot showing TbTRF-Ty1 interacting proteins. In both plots only the overlapping candidates are shown (complete datasets are summarized in Supplementary Tables S1 and 2). Six telomeric proteins were identified in both the experiments: TbTIF2, TbTRF, Tb927.6.4330, Tb927.11.5550, Tb927.9.4000/3930 and Tb927.11.9870. The candidate Tb927.11.9870, which was selected for detailed analyses, is highlighted in red.