Figure 2.

HSC-EXs^miR126 co-culture remarkably promoted the differentiation of ESCs into HSCs. (A) Representative flow cytometry plots showing the percentage of HSCs after 10-d differentiation. (B) Summarized data showing that HSC-EXs^con and HSC-EXs^sc treatment promoted the differentiation of ESCs into HSCs, with the greatest differentiation promoted by HSC-EX^miR126. This effect was attenuated by Jagged1. ^*P<0.05 vs con. ⁺P<0.05 vs HSC-EXs^con, or HSC-EXs^sc, or Jagged1, or HSC-EXs^miR126+Jagged1. Data are expressed as the mean±SEM. n=4.