Table 2.
Follow-up characteristics and outcomes by ISN/RPS class
| Patient characteristics | Class II (n = 47) | Class III-A (n = 20) | Class III-AC (n = 19) | Class IV-A (n = 70) | Class IV-AC (n = 63) | Class III/IV + V (n = 19) | Class V (n = 61) |
|---|---|---|---|---|---|---|---|
| Renal follow-up, n (%) | 33 (70) | 13 (65) | 16 (84) | 54 (77) | 45 (71) | 17 (89) | 40 (66) |
| Mean follow-up (years) | 7.2 (4.8) | 7.4 (5.2) | 7.9 (5.1) | 8.1 (5.1) | 5.7 (4.7) | 4.1 (3.7) | 7.2 (4.3) |
| BP systolic (mmHg) | 122 (17) | 126 (17) | 128 (17) | 131 (22) | 132 (23) | 132 (23) | 125 (16) |
| BP diastolic (mmHg) | 77 (10) | 79 (10) | 78 (11) | 80 (14) | 79 (13) | 78 (12) | 78 (12) |
| C3 (mg/dL) | 98 (36) | 121 (29) | 99 (36) | 91 (31) | 76 (37) | 94 (34) | 103 (30) |
| C4 (mg/dL) | 20 (10) | 24 (11) | 25 (13) | 19 (11) | 13 (11) | 18 (6) | 23 (12) |
| Anti-dsDNA (IU/mL) | 134 (217) | 48 (69) | 135 (307) | 121 (233) | 215 (458) | 81 (72) | 96 (185) |
| Urine protein/Cr (mg/mg) | 0.51 (0.79) | 1.70 (3.25) | 1.79 (2.73) | 2.53 (4.17) | 6.0 (16.5) | 2.60 (3.48) | 1.92 (3.32) |
| SCr (mg/dL) | 1.10 (0.93) | 1.22 (1.18) | 1.25 (0.99) | 1.87 (2.95) | 2.7 (2.4) | 1.36 (1.16) | 1.54 (1.60) |
| Outcome categories in patients alive at last follow-up | |||||||
| eGFR (mL/min/1.73 m2), n | |||||||
| ≥90 | 15 | 6 | 7 | 18 | 7 | 7 | 19 |
| ≥60–< 90 | 8 | 3 | 2 | 10 | 5 | 2 | 7 |
| ≥30–< 60 | 5 | 2 | 4 | 9 | 7 | 1 | 3 |
| ≥15–< 30 | 1 | 0 | 0 | 1 | 1 | 1 | 2 |
| <15 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| Dialysis living | 0 | 0 | 1 | 3 | 12 | 2 | 4 |
| Kidney transplant living | 0 | 1 | 0 | 3 | 5 | 0 | 1 |
| Outcome categories in patients that died during the study period, n | |||||||
| Death after dialysis | 2 | 1 | 0 | 3 | 6 | 1 | 2 |
| Death after transplant | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Death with CKD | 0 | 0 | 1 | 4 | 1 | 1 | 0 |
| Death without CKD | 1 | 0 | 1 | 2 | 0 | 0 | 0 |
| Death with unknown kidney function | 2 | 1 | 0 | 4 | 4 | 0 | 1 |
| Composite outcomes | |||||||
| ESRD or RRT, total n (%) | 3 (6) | 2 (10) | 2 (11) | 10 (14) | 24 (38) | 3 (16) | 9 (15) |
| All-cause death, total n (%) | 5 (11) | 2 (10) | 2 (11) | 14 (20) | 12 (19) | 2 (11) | 3 (5) |
BP, blood pressure; C3, complement component 3; C4, complement component 4; CKD, chronic kidney disease; dsDNA, double-stranded DNA; SCr, serum creatinine.