Table 3.
Proportional hazards model for renal survival
| Patient and biopsy characteristics | Univariate | P-value | Multivariable with complete cases (n = 132) | P-value | Multivariable after multiple imputation (n = 191) | P-value |
|---|---|---|---|---|---|---|
| Class IV | 2.19 (1.22–3.95) | 0.008 | ||||
| IFTA category (%) | Relative to IFTA <5% | <0.001 | 2.20 (1.29–3.74) | 0.004 | 1.40 (1.05–1.87) | 0.048 |
| ≥5–25 | 2.36 (1.13–4.90) | 0.021 | ||||
| ≥25–50 | 3.84 (1.53–9.62) | 0.004 | ||||
| ≥50 | 7.67 (3.75–15.67) | <0.001 | ||||
| Inflammation grade (%) | Relative to II < 5% | <0.001 | 1.58 (1.06–2.36) | 0.024 | 1.39 (1.08–1.79) | 0.028 |
| ≥5–25 | 2.14 (1.09–4.20) | 0.027 | ||||
| ≥25–50 | 4.21 (1.93–9.16) | <0.001 | ||||
| ≥50 | 11.41 (4.97–26.16) | <0.001 | ||||
| Proportion globally sclerosed glomeruli | 4.82 (1.64–14.15) | 0.004 | ||||
| Necrosis | 1.82 (1.05–3.14) | 0.031 | ||||
| Crescents | 1.47 (0.83–2.60) | 0.177 | ||||
| Arteriosclerosis | 1.28 (0.91–1.80) | 0.142 | ||||
| Age (years) | 0.99 (0.98–1.01) | 0.909 | 0.96 (0.93–0.99) | 0.036 | 0.99 (0.97–1.02) | 0.871 |
| Male | 0.89 (0.43–1.83) | 0.762 | 3.02 (1.02–8.92) | 0.044 | 1.01 (0.44–2.29) | 0.980 |
| Non-Hispanic White | 0.72 (0.40–1.30) | 0.284 | 0.69 (0.27–1.78) | 0.454 | 0.98 (0.49–1.94) | 0.958 |
| African American | 1.36 (0.75–2.48) | 0.307 | ||||
| Hispanic | 1.28 (0.68–2.39) | 0.431 | ||||
| SCr (mg/dL) | 2.05 (1.61–2.62) | <0.001 | 2.16 (1.50–3.11) | <0.001 | 1.68 (1.35–2.08) | <0.001 |
| BMI (kg/m2) | 0.96 (0.91–1.00) | 0.094 | ||||
| BP systolic (mmHg) | 1.16 (1.02–1.32) | 0.017 | ||||
| BP diastolic (mmHg) | 1.08 (1.01–1.17) | 0.024 | ||||
| Serum albumin (g/dL) | 0.59 (0.35–0.99) | 0.046 | ||||
| WBC count (1000/µL) | 0.94 (0.82–1.07) | 0.381 | ||||
| Hematocrit (%) | 0.89 (0.81–0.97) | 0.005 | ||||
| Platelet count (1000/µL) | 1.00 (0.99–1.00) | 0.470 | ||||
| 24-h protein (g) | 1.17 (1.06–1.28) | 0.001 | ||||
| Urine Pr/Cr (mg/mg) | 0.78 (0.49– 1.23) | 0.295 | ||||
| C3 (mg/dL) | 0.99 (0.98–1.00) | 0.335 | ||||
| C4 (mg/dL) | 0.99 (0.95–1.04) | 0.861 | ||||
| Anti-dsDNA positive | 0.87 (0.37–2.07) | 0.762 | ||||
| Diabetes | 1.28 (0.57–2.89) | 0.545 | ||||
| Family history of rheumatic disease | 1.61 (0.87–3.85) | 0.285 |
BMI, body mass index; BP, blood pressure; C3, complement component 3; C4, complement component 4; Cr, creatinine; dsDNA, double-stranded DNA; II, interstitial inflammation; Pr, protein; SCr, serum creatinine; WBC, white blood cells.