Table 2.
Significant differentially expressed genes in the MAPK-signaling pathway where fold change is <0.67 or >1.50.
| Gene name | Tumor mean | Normal mean | Fold change | P value | Adjusted P value |
|---|---|---|---|---|---|
| Downregulated | |||||
| FGF9 | 1.66 | 9.08 | 0.18 | 4.27E−30 | 6.44E−29 |
| PPP3R2 | 0.20 | 0.93 | 0.21 | 3.56E−07 | 8.02E−07 |
| CACNG3 | 0.16 | 0.62 | 0.25 | 4.46E−04 | 7.32E−04 |
| CACNG7 | 0.17 | 0.67 | 0.25 | 1.91E−05 | 3.48E−05 |
| CACNA1A | 3.27 | 12.58 | 0.26 | 2.27E−32 | 4.57E−31 |
| CACNA1G | 1.26 | 4.80 | 0.26 | 4.08E−16 | 1.79E−15 |
| CACNA1F | 1.68 | 6.25 | 0.27 | 1.60E−21 | 1.01E−20 |
| RASGRP2 | 6.72 | 24.73 | 0.27 | 1.04E−31 | 1.93E−30 |
| PRKCB | 14.65 | 53.12 | 0.28 | 1.52E−41 | 7.31E−40 |
| CACNA1I | 1.91 | 6.56 | 0.29 | 8.80E−19 | 4.51E−18 |
| MAPK10 | 9.26 | 28.10 | 0.33 | 8.93E−34 | 1.96E−32 |
| MAP4K1 | 7.24 | 21.46 | 0.34 | 1.58E−26 | 1.74E−25 |
| CACNG2 | 0.21 | 0.57 | 0.37 | 2.28E−03 | 3.41E−03 |
| PRKACB | 62.60 | 162.73 | 0.38 | 5.72E−40 | 1.97E−38 |
| FGFR2 | 26.51 | 68.82 | 0.39 | 2.32E−21 | 1.40E−20 |
| MEF2C | 27.15 | 66.82 | 0.41 | 1.00E−41 | 6.02E−40 |
| FOS | 185.52 | 453.52 | 0.41 | 9.65E−31 | 1.66E−29 |
| CACNG1 | 0.27 | 0.65 | 0.42 | 3.35E−05 | 5.89E−05 |
| FGF10 | 1.70 | 4.06 | 0.42 | 1.85E−10 | 5.45E−10 |
| PTPN5 | 0.89 | 2.09 | 0.42 | 7.08E−07 | 1.55E−06 |
| DUSP1 | 67.66 | 154.53 | 0.44 | 1.02E−34 | 2.46E−33 |
| EGF | 2.83 | 6.34 | 0.45 | 1.71E−05 | 3.15E−05 |
| CACNB2 | 26.71 | 59.55 | 0.45 | 1.00E−38 | 3.03E−37 |
| IL1R2 | 7.02 | 15.61 | 0.45 | 1.00E−13 | 3.77E−13 |
| NTRK1 | 1.10 | 2.43 | 0.45 | 3.24E−07 | 7.36E−07 |
| CACNA1B | 1.79 | 3.91 | 0.46 | 1.99E−06 | 4.14E−06 |
| NTRK2 | 17.81 | 38.41 | 0.46 | 1.04E−08 | 2.67E−08 |
| DUSP5 | 28.27 | 59.40 | 0.48 | 1.39E−22 | 9.28E−22 |
| CACNA1H | 53.11 | 106.08 | 0.50 | 5.22E−27 | 5.99E−26 |
| FGFR3 | 36.15 | 70.78 | 0.51 | 1.13E−18 | 5.54E−18 |
| MAPT | 4.51 | 8.74 | 0.52 | 1.01E−12 | 3.40E−12 |
| NFATC1 | 12.01 | 22.97 | 0.52 | 3.23E−17 | 1.50E−16 |
| PDGFRA | 88.47 | 166.61 | 0.53 | 5.08E−26 | 5.11E−25 |
| CACNA2D3 | 1.56 | 2.91 | 0.53 | 1.46E−04 | 2.46E−04 |
| MAPK7 | 21.28 | 38.75 | 0.55 | 6.78E−29 | 9.08E−28 |
| FAS | 28.16 | 50.95 | 0.55 | 2.75E−24 | 2.46E−23 |
| CACNA1S | 0.56 | 1.00 | 0.56 | 6.90E−03 | 1.00E−02 |
| RASGRP1 | 21.77 | 38.90 | 0.56 | 1.20E−22 | 8.23E−22 |
| PRKACG | 0.17 | 0.31 | 0.56 | 1.84E−03 | 2.79E−03 |
| RASGRP3 | 25.53 | 45.22 | 0.56 | 1.16E−20 | 6.81E−20 |
| FGF2 | 10.04 | 17.66 | 0.57 | 2.79E−13 | 9.89E−13 |
| FGF13 | 2.42 | 4.18 | 0.58 | 2.84E−05 | 5.06E−05 |
| vRAC2 | 22.11 | 37.39 | 0.59 | 4.70E−16 | 2.02E−15 |
| FGF7 | 8.17 | 13.70 | 0.60 | 1.49E−08 | 3.69E−08 |
| NTF3 | 0.84 | 1.41 | 0.60 | 1.04E−03 | 1.61E−03 |
| RPS6KA1 | 89.25 | 148.07 | 0.60 | 1.24E−30 | 2.00E−29 |
| JUND | 127.78 | 210.71 | 0.61 | 1.88E−36 | 5.04E−35 |
| PLA2G4F | 22.98 | 37.48 | 0.61 | 2.67E−10 | 7.76E−10 |
| CACNA2D2 | 10.30 | 16.63 | 0.62 | 1.02E−08 | 2.63E−08 |
| RPS6KA5 | 18.57 | 29.87 | 0.62 | 1.84E−15 | 7.76E−15 |
| FLNC | 46.98 | 75.44 | 0.62 | 3.90E−09 | 1.02E−08 |
| ARRB1 | 52.99 | 84.74 | 0.63 | 4.44E−24 | 3.61E−23 |
| NR4A1 | 201.17 | 319.66 | 0.63 | 5.51E−11 | 1.72E−10 |
| FASLG | 1.07 | 1.70 | 0.63 | 4.96E−03 | 7.29E−03 |
| IL1R1 | 57.71 | 89.40 | 0.65 | 9.55E−17 | 4.34E−16 |
| HSPA2 | 7.29 | 11.21 | 0.65 | 5.51E−06 | 1.08E−05 |
| PTPN7 | 16.22 | 24.78 | 0.65 | 3.08E−08 | 7.57E−08 |
| MAP3K14 | 33.86 | 51.73 | 0.65 | 1.46E−24 | 1.35E−23 |
| MAP2K6 | 25.29 | 38.55 | 0.66 | 1.60E−10 | 4.77E−10 |
| MKNK1 | 63.58 | 95.95 | 0.66 | 2.04E−27 | 2.46E−26 |
| Upregulated | |||||
| HSPB1 | 60.24 | 40.01 | 1.51 | 3.87E−12 | 1.24E−11 |
| TGFBR1 | 106.44 | 70.13 | 1.52 | 6.14E−19 | 3.21E−18 |
| STK3 | 41.26 | 26.65 | 1.55 | 1.64E−18 | 7.88E−18 |
| HSPA6 | 5.49 | 3.43 | 1.60 | 3.67E−05 | 6.40E−05 |
| ELK1 | 49.96 | 30.79 | 1.62 | 4.90E−24 | 3.81E−23 |
| DUSP10 | 27.04 | 16.22 | 1.67 | 3.95E−14 | 1.59E−13 |
| FGF1 | 4.77 | 2.79 | 1.71 | 9.30E−06 | 1.75E−05 |
| TP53 | 105.07 | 59.63 | 1.76 | 3.25E−24 | 2.79E−23 |
| HSPA1B | 102.12 | 55.34 | 1.85 | 4.49E−24 | 3.61E−23 |
| PDGFRB | 166.24 | 87.76 | 1.89 | 8.03E−28 | 1.02E−26 |
| TGFB2 | 9.23 | 4.52 | 2.04 | 8.04E−14 | 3.13E−13 |
| FGF18 | 1.90 | 0.85 | 2.22 | 1.27E−05 | 2.36E−05 |
| HSPA8 | 631.28 | 273.40 | 2.31 | 5.34E−56 | 1.29E−53 |
| CACNG8 | 7.57 | 3.27 | 2.32 | 7.89E−10 | 2.19E−09 |
| STMN1 | 77.81 | 31.07 | 2.50 | 1.15E−40 | 4.63E−39 |
| DUSP4 | 56.69 | 21.44 | 2.64 | 2.53E−22 | 1.65E−21 |
| CDC25B | 169.88 | 60.96 | 2.79 | 9.71E−54 | 7.80E−52 |
| IL1A | 7.56 | 2.39 | 3.17 | 2.02E−19 | 1.08E−18 |
| NTF4 | 0.55 | 0.17 | 3.23 | 3.80E−06 | 7.57E−06 |
| CACNG4 | 3.41 | 1.03 | 3.30 | 8.11E−10 | 2.22E−09 |
| MYC | 181.11 | 49.00 | 3.70 | 5.76E−55 | 6.94E−53 |
| FGF20 | 0.72 | 0.14 | 5.29 | 2.29E−05 | 4.15E−05 |
| FGF19 | 1.39 | 0.15 | 9.42 | 6.08E−13 | 2.12E−12 |