Table 3.
Associations between MAPK pathway–dysregulated mRNA and miRNAs.
| Gene name | Tumor mean | Normal mean | Fold change | MiRNA | Tumor mean | Normal mean | Fold change | β | Raw P value | FDR P value |
|---|---|---|---|---|---|---|---|---|---|---|
| RASGRP2 | 6.72 | 24.73 | 0.27 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .31 | <.0001 | .0407 |
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .29 | .0002 | .0407 | ||||
| MEF2C | 27.15 | 66.82 | 0.41 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .35 | <.0001 | .0116 |
| hsa-miR-193b-3p | 9.12 | 5.42 | 1.68 | .28 | <.0001 | .0116 | ||||
| hsa-miR-195-5p | 3.59 | 12.18 | 0.29 | .25 | .0004 | .025 | ||||
| hsa-miR-203a | 12.52 | 3.70 | 3.38 | −.30 | <.0001 | .0116 | ||||
| hsa-miR-221-3p | 13.53 | 4.12 | 3.28 | −.26 | .0002 | .0148 | ||||
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .34 | <.0001 | .0116 | ||||
| MAP4K1 | 7.24 | 21.46 | 0.34 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .30 | <.0001 | .0203 |
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .30 | .0003 | .0488 | ||||
| TGFBR1 | 106.44 | 70.13 | 1.52 | hsa-let-7i-5p | 62.16 | 39.97 | 1.56 | .25 | .0006 | .031 |
| hsa-miR-1203 | 1.76 | 2.83 | 0.62 | −.23 | .0007 | .031 | ||||
| hsa-miR-199a-3p | 44.83 | 22.53 | 1.99 | .24 | .0007 | .031 | ||||
| hsa-miR-199a-5p | 20.18 | 9.28 | 2.17 | .22 | .0016 | .0458 | ||||
| hsa-miR-2117 | 1.50 | 4.09 | 0.37 | −.22 | .0011 | .0358 | ||||
| hsa-miR-214-3p | 13.24 | 6.13 | 2.16 | .26 | .0005 | .031 | ||||
| hsa-miR-21-5p | 463.11 | 167.37 | 2.77 | .25 | .0006 | .031 | ||||
| hsa-miR-23a-3p | 174.68 | 87.53 | 2.00 | .25 | .0008 | .031 | ||||
| hsa-miR-24-3p | 106.75 | 62.39 | 1.71 | .24 | .0009 | .0318 | ||||
| hsa-miR-331-3p | 14.64 | 9.30 | 1.57 | .24 | .0006 | .031 | ||||
| hsa-miR-6071 | 0.97 | 1.70 | 0.57 | −.22 | .0017 | .0458 | ||||
| HSPA8 | 631.28 | 273.40 | 2.31 | hsa-miR-17-5p | 61.04 | 16.38 | 3.73 | .27 | .0003 | .0407 |
| hsa-miR-203a | 12.52 | 3.70 | 3.38 | .35 | <.0001 | .0271 | ||||
| hsa-miR-221-3p | 13.53 | 4.12 | 3.28 | .28 | <.0001 | .0271 | ||||
| hsa-miR-29b-3p | 24.31 | 9.83 | 2.47 | .27 | .0003 | .0407 | ||||
| hsa-miR-93-5p | 41.72 | 15.20 | 2.74 | .25 | .0003 | .0407 | ||||
| PDGFRB | 166.24 | 87.76 | 1.89 | hsa-miR-193b-3p | 9.12 | 5.42 | 1.68 | .27 | .0002 | .0181 |
| hsa-miR-199a-3p | 44.83 | 22.53 | 1.99 | .33 | <.0001 | .0102 | ||||
| hsa-miR-199a-5p | 20.18 | 9.28 | 2.17 | .35 | <.0001 | .0102 | ||||
| hsa-miR-199b-5p | 4.69 | 1.53 | 3.07 | .34 | <.0001 | .0102 | ||||
| hsa-miR-214-3p | 13.24 | 6.13 | 2.16 | .38 | <.0001 | .0102 | ||||
| hsa-miR-934 | 4.36 | 0.94 | 4.66 | .46 | <.0001 | .0102 | ||||
| IL1R1 | 57.71 | 89.40 | 0.65 | hsa-miR-193b-3p | 9.12 | 5.42 | 1.68 | .31 | <.0001 | .0203 |
| hsa-miR-214-3p | 13.24 | 6.13 | 2.16 | .27 | .0003 | .0407 | ||||
| DUSP4 | 56.69 | 21.44 | 2.64 | hsa-miR-193b-3p | 9.12 | 5.42 | 1.68 | −.27 | <.0001 | .0163 |
| hsa-miR-196b-5p | 17.89 | 5.53 | 3.24 | −.31 | <.0001 | .0163 | ||||
| hsa-miR-424-3p | 39.81 | 25.37 | 1.57 | −.29 | .0003 | .0271 | ||||
| RAC2 | 22.11 | 37.39 | 0.59 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .39 | <.0001 | .0203 |
| hsa-miR-203a | 12.52 | 3.70 | 3.38 | −.28 | <.0001 | .0203 | ||||
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .36 | <.0001 | .0203 | ||||
| PDGFRA | 88.47 | 166.61 | 0.53 | hsa-miR-145-5p | 132.97 | 223.14 | 0.60 | .26 | .0002 | .0163 |
| hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .24 | .0004 | .0233 | ||||
| hsa-miR-17-5p | 61.04 | 16.38 | 3.73 | −.28 | <.0001 | .0136 | ||||
| hsa-miR-19b-3p | 29.80 | 10.42 | 2.86 | −.29 | <.0001 | .0136 | ||||
| hsa-miR-203a | 12.52 | 3.70 | 3.38 | −.30 | <.0001 | .0136 | ||||
| hsa-miR-20a-5p | 70.78 | 17.61 | 4.02 | −.28 | .0002 | .0163 | ||||
| hsa-miR-20b-5p | 17.65 | 3.30 | 5.35 | −.30 | <.0001 | .0136 | ||||
| hsa-miR-29b-3p | 24.31 | 9.83 | 2.47 | −.27 | .0003 | .0222 | ||||
| hsa-miR-501-3p | 7.07 | 2.95 | 2.39 | −.25 | .0004 | .0233 | ||||
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .32 | <.0001 | .0136 | ||||
| MYC | 181.11 | 49.00 | 3.70 | hsa-miR-1246 | 629.21 | 412.81 | 1.52 | .27 | .0002 | .0163 |
| hsa-miR-17-5p | 61.04 | 16.38 | 3.73 | .35 | <.0001 | .0136 | ||||
| hsa-miR-19b-3p | 29.80 | 10.42 | 2.86 | .27 | .0002 | .0163 | ||||
| hsa-miR-20a-5p | 70.78 | 17.61 | 4.02 | .33 | <.0001 | .0136 | ||||
| hsa-miR-20b-5p | 17.65 | 3.30 | 5.35 | .31 | .0002 | .0163 | ||||
| hsa-miR-3651 | 58.66 | 25.92 | 2.26 | .28 | .0003 | .0188 | ||||
| hsa-miR-375 | 20.50 | 54.53 | 0.38 | −.29 | <.0001 | .0136 | ||||
| hsa-miR-501-3p | 7.07 | 2.95 | 2.39 | .26 | .0003 | .0188 | ||||
| hsa-miR-583 | 6.61 | 3.22 | 2.05 | .26 | .0004 | .0233 | ||||
| hsa-miR-663a | 374.83 | 234.91 | 1.60 | .28 | .0003 | .0188 | ||||
| hsa-miR-663b | 65.50 | 32.21 | 2.03 | .33 | <.0001 | .0136 | ||||
| hsa-miR-92a-3p | 121.60 | 41.18 | 2.95 | .32 | <.0001 | .0136 | ||||
| RASGRP3 | 25.53 | 45.22 | 0.56 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .35 | <.0001 | .0203 |
| hsa-miR-429 | 13.33 | 8.29 | 1.61 | −.25 | .0003 | .0407 | ||||
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .35 | <.0001 | .0203 | ||||
| PRKCB | 14.65 | 53.12 | 0.28 | hsa-miR-150-5p | 14.90 | 39.17 | 0.38 | .38 | <.0001 | .0102 |
| hsa-miR-203a | 12.52 | 3.70 | 3.38 | −.30 | <.0001 | .0102 | ||||
| hsa-miR-650 | 4.51 | 16.60 | 0.27 | .35 | <.0001 | .0102 |
Abbreviations: FDR, false discovery rate; mRNA, messenger RNA; miRNA, microRNA.
Bold text indicates seed region match between miRNA and mRNA.