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. 2018 Mar 26;19(1):1470320318759358. doi: 10.1177/1470320318759358

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Exogenous CTGF incubation does not appear to have an effect on NIH/3T3 fibroblast production of fibrogenic CTGF, TGF-β or collagen type I transcripts independently or synergistically with exogenous TGF-β incubation in vitro. NIH/3T3 fibroblasts were incubated with exogenous CTGF only, TGF-β only, or CTGF plus TGF-β for six hours. Transcript levels of (a) CTGF, (b) TGF-β and (c) collagen type I were obtained using qPCR analyses. Transcript levels are reported relative to housekeeping genes ribosomal 18S and GAPDH.

Data are represented as means ± SEM and expressed relative to media control.

n = 3 independent experiments in triplicate.

*p<0.05, **p ≤ 0.01, compared to media control.

CTGF: connective tissue growth factor; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; qPCR: quantitative polymerase chain reaction; TGF-β: transforming growth factor-β.