Figure 7.

Administration of TGF-β trap reduced levels of Ang-II-induced early upregulation of CTGF transcript levels at six hours. Myocardial CTGF and TGF-β transcript levels after (a) six hours or (b) 24 hours of Ang-II infused animals injected with TGF-β trap or PBS relative to saline controls. Transcript levels are reported relative to housekeeping gene ribosomal 18S.

Data are expressed as means ± SEM.

n = 5–6.

*p < 0.05, compared to PBS group.

Ang-II: Angiotensin II; CTGF: connective tissue growth factor; PBS: phosphate-buffered saline; Trap: TGF-β trap; TGF-β: transforming growth factor-β.