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. 2017 Dec 7;162(2):396–405. doi: 10.1093/toxsci/kfx268

Figure 2.

Figure 2.

Effect of IDN-7314 administration on cleaved caspase-3 levels in Fas-induced liver injury in mice. Wild-type mice were given a single injection of Jo2 (0.35 mg/kg) or vehicle (saline), then treated with 3 mg/kg IDN-7314 or vehicle (50% DMSO) 1 h later. Liver samples were collected 4½ h after Jo2 administration. (A) Western blots showing hepatic levels of cleaved caspase-3 and Gapdh protein with (B) corresponding densitometry quantification (n = 3 mice per group). Data are expressed as mean + SEM. *p < .05.