Table 3.
Diagnostic Cases With Normal Karyotype and Abnormal FISH
| Case No. | Blasts, % | FISH, %a | FISH Abnormality Detected |
|---|---|---|---|
| 1 | 29 | 4.5 | Loss of RARA (17q21) |
| 2 | 20 | 2 | Gain of RUNX1 (21q22) |
| 3 | 45 | 9.5 | Gain of RUNX1T1 (8q21.3) |
| 4 | 31 | 7.5 | Loss of RARA (17q21) |
| 5 | 53 | 4.5 | Loss of RARA (17q21) |
| 6 | 68 | 7 | Loss of RUNX1 (21q22) |
| 7 | 49 | 64-72 | Extra copies of multiple probes |
| 8 | 65 | 9 | Loss and gain of CBFB (16q22) |
| 9 | 71 | 74.5 | Gain of KMT2A (11q23) |
| 10 | 86 | 37.5 | PML/RARA (cryptic insertion of RARA into PML) |
FISH, fluorescence in situ hybridization.
aPercent cells positive for abnormal pattern out of 200 total cells analyzed.