Table 5.

Follow-up Cases With Normal Karyotype and Abnormal FISH

Case No.	FISH Abnormality	FISH Abnormal, %a	Morphology	Time From Diagnosis, d	Clinical Follow-up
1	inv(16)	2	–	29	Relapse within 1 year, deceased
2	inv(16)	2.7	–	14	Successful BM transplant
3	inv(16)	1.5	+	14	Relapse at 1 year → remission
4	inv(16)	1.5	–	15	No evidence of relapse
5	inv(16)	3	–	15	Relapse at 1 year → remission
6	KMT2A b	1	–	93	Relapse within 1 year, deceased
7	KMT2A b	6	+	120	Relapse within 1 year, deceased
8	t(10;21)	1	–	120	Relapse within 1 year, deceased
9	t(15;17)	1	–	54	No evidence of relapse
10	Loss of RARA	4.7	–	47	No evidence of relapse
11	Loss of RARAb	3	–	32	No evidence of relapse
12	Loss of RARAb	4	–	122	No evidence of relapse
13	Loss of RUNX1b	6.5	–	31	Successful BM transplant
14	Loss of RUNX1b	4	–	83	Successful BM transplant
15	Gain of RUNX1T1	9	+	406	Relapse within 1 year
16	Gain of RUNX1	3.5	–	816	Relapse within 1 year, deceased
17	Loss of RUNX1/loss of KMT2A	4/3	–	18	No follow-up available

BM, bone marrow; FISH, fluorescence in situ hybridization; +, positive; –, negative.

^aPercent cells positive for abnormal pattern out of 200 total.

^bCases 6 and 7, same patient; cases 11 and 12, same patient; cases 13 and 14, same patient.