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. 2017 Dec 20;162(2):611–621. doi: 10.1093/toxsci/kfx283

Figure 5.

Figure 5.

Determination of therapeutic window of AEOL10150 against oxidative stress markers in plasma. The levels of (A) Cys, (B) Cyss, (C) Cys/Cyss, (D) GSH, (E) GSSG, and (F) GSH/GSSG in plasma of rats 24 h after DFP with standard therapy alone or with AEOL10150. Midazolam 2 mg/kg i.m. treated at same time point with AEOL10150 when AEOL10150 is given 5 min (7 mg/kg, s.c.) or 15 min (5 mg/kg, s.c.) after SE initiation and 5 mg/kg s.c. or saline every 4 h thereafter. Bars represent mean + SEM, *p < .01 versus saline + standard therapy, #p < .05 versus DFP + standard therapy + saline, 2-way ANOVA, n = 6 per group.