Table 1.
ROS | Superoxide | Hydrogen peroxide | Lipid Peroxides | Peroxynitrite | |
---|---|---|---|---|---|
Activity | kcat() = 6.78 × 107 M−1 s−1 | k(H2O2) = 2.2 min−1 | F2-IP IC50 = 0.1 µM | k(ONOO−) = 1.01 × 107 M−1 s −1 |
Structure of metalloporphyrin catalytic antioxidant AEOL10150. The effect of AEOL10150 to destroy superoxide (as measured by pulse radiolysis), hydrogen peroxide (Clark oxygen electrode), peroxynitrite (stop-flow) and inhibit lipid peroxidation (F2-isoprostanes) (Kachadourian et al., 2004).