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. 2017 Dec 7;162(2):439–449. doi: 10.1093/toxsci/kfx270

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Figure 3. — Effects of HU exposure in embryos on the relative expression of genes that are downstream targets of unique P53 family proteins. A, Selected candidates of unique downstream targets of P53, P63, and P73. B–E, Relative expression levels of Trp53inp1, Pax9, Tbx5, and Jag2. Each bar represents the fold change of the mean quantity of the transcript relative to Hprt. C, control; HU, hydroxyurea. P < .05, 2-way ANOVA followed by a Bonferroni post hoc test, n = 3. (*) denotes significant change compared with control group with the same genotype and (b) denotes significant change compared with the Trp53^+/+ HU-treated group.