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. 2017 Dec 7;162(2):439–449. doi: 10.1093/toxsci/kfx270

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Figure 5. — Effects of HU exposure on the cleavage of caspase-3 and mammalian sterile-20-like-1 (MST-1) and H2AX phosphorylation in embryos. Representative Western blots and quantification of cleaved caspase-3 (A and B), cleaved MST-1 (C and D) and γH2AX (E and F) protein expression levels, normalized to the loading control, actin. Each bar represents the fold change of the mean quantity of the protein relative to actin. C, control, HU, hydroxyurea. P < .05, 2-way ANOVA followed by a Bonferroni post hoc test, n = 3. (*) denotes significant change compared with control group with the same genotype and (b) denotes significant change compared with the Trp53^+/+ HU-treated group.