Figure 1.
Diagram of phase I–II trial design. Based on the most recent data, the optimal dose is defined as the dose that maximizes the efficacy–toxicity trade-off.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.