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Summary of BSEP and MRP3 In Vitro Transport Inhibition and DILI Assessment for the Morgan et al. (2013) Dataset
| Criteria | % of Drugs With DILI Predicted Correctly, PPV | % of DILI Missing in the Prediction, FNR | % of DILI Predicted Accurately, ACC (n = 109) |
|---|---|---|---|
| Css/IC50 BSEP Inhibition ≥ 0.1 | 94.4% | 51.4% | 65.1% |
| Above + Css/IC50 MRP 2, 3, or 4 Inhibition ≥ 0.1 | 92.9% | 81.4% | 46.8% |
