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Summary of BSEP and MRP3 In Vitro Transport Inhibition and DILI Assessment for the Morgan et al. (2013) Dataset for Only BDDCS Classifiable Drugs
| Criteria | % of Drugs With DILI Predicted Correctly, PPV | % of DILI Missing in the Prediction, FNR | % of DILI Predicted Accurately, ACC (n = 99) |
|---|---|---|---|
| Css/IC50 BSEP Inhibition ≥ 0.1 | 93.5% | 54.0% | 63.6% |
| Above + Css/IC50 MRP 2, 3 or 4 Inhibition ≥ 0.1 | 90.0% | 85.7% | 44.4% |
| BDDCS Class 2 | 70.7% | 15.9% | 67.7% |
