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. 2018 Mar 6;18(3):foy026. doi: 10.1093/femsyr/foy026

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© FEMS 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Genetic regulation of early steps of [PSI⁺] appearance (adapted from Sharma et al. 2017). Overexpression of the prion-determining domain of Sup35 fused to GFP in [PIN⁺] yeast cells leads to the appearance and evolution of microscopically visible protein aggregates of distinct types: rings (pathway 1), single dots (pathway 2), lines (pathway 3) and multiple dots (pathway 4), which all lead to [PSI⁺] appearance (Sharma et al. 2017). Deletion mutants (red), which reduce [PSI⁺] appearance, differentially impact the appearance and/or accumulation of these visible aggregates (e.g. Δlas17, Δvps5 or Δsac6) or appear to act downstream of these events (e.g. Δbug1, Δbem1, Δarf1 or Δhog1) (Manogaran et al. 2011; Sharma et al. 2017; Wisniewski et al. 2018).