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. Author manuscript; available in PMC: 2019 Jan 11.
Published in final edited form as: J Med Chem. 2017 Oct 27;61(1):84–97. doi: 10.1021/acs.jmedchem.7b00932

Table 5. Tetrahydropyridine variants.

Protective activity of tetrahydropyridine variants in the zebrafish hair cell protection assay. NA – not active (HC50 > 25 μM).

graphic file with name nihms953119u6.jpg R1/R2 HC50 (μM)
1 graphic file with name nihms953119t42.jpg 3.12
39 graphic file with name nihms953119t43.jpg 4.70
40 graphic file with name nihms953119t44.jpg 3.26
41 graphic file with name nihms953119t45.jpg 4.61
42 graphic file with name nihms953119t46.jpg 4.34
43 graphic file with name nihms953119t47.jpg 3.98
44 graphic file with name nihms953119t48.jpg 5.80
45 graphic file with name nihms953119t49.jpg 6.92
46 graphic file with name nihms953119t50.jpg NA
47 graphic file with name nihms953119t51.jpg NA
48 graphic file with name nihms953119t52.jpg NA