Skip to main content
. Author manuscript; available in PMC: 2018 Apr 6.
Published in final edited form as: Cell Rep. 2016 Nov 15;17(8):2101–2111. doi: 10.1016/j.celrep.2016.10.054

Figure 1. Genome-wide DNA Methylation Trends in Cells of the Lymphoid and Myeloid Lineages.

Figure 1

(A) Methylation in CH and CG contexts in lymphoid (triangles) and myeloid cells (circles). Long-lived lymphoid cells have lower CG methylation. Naive T cells have higher levels of non-CG methylation. Most myeloid-derived cancers gain non-CG methylation.

(B) CG methylation. Developing lymphocytes lose methylation (left). Cells of the myeloid lineage are relatively constant or show small gains in methylation (right).

(C) Fraction of non-CG cytosines methylated. Fraction methylated is computed as the number of significantly methylated non-CG cytosines divided by the total number of non-CG cytosines read with adequate coverage to make a methylation call, as described in Experimental Procedures. Stem cell: HUES64 cell line; progenitor: CD34+, including stem cells, multipotent progenitors, and common lymphoid progenitors. Numbers indicate developmental order relative to the indicated cell type. Blue, female; red, male.