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. Author manuscript; available in PMC: 2018 Apr 6.
Published in final edited form as: Cell Rep. 2016 Nov 15;17(8):2101–2111. doi: 10.1016/j.celrep.2016.10.054

Figure 4. DNA Methylation Levels at Successive Stages of B Lymphocyte Development Aggregated across Subsets of CTCF-Binding Sites.

Figure 4

Development occurs in the order indicated in the legend, with UHP being the least differentiated cell type.

(A) Methylation surrounding 23,710 constitutively occupied CTCF-binding sites shows oscillations that increase in amplitude as lymphocytes develop.

(B–D) CTCF-binding sites specifically occupied in (B) lymphoblastoid cell line, (C) stem cell line (unoccupied in B cells), and (D) skin cell line (unoccupied in B cells). GC, germinal center B cell; PC, plasma cell; UHP, uncommitted hematopoietic progenitor. See also Figures S2 and S3.