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. Author manuscript; available in PMC: 2018 Apr 6.
Published in final edited form as: Cell Rep. 2018 Feb 13;22(7):1798–1809. doi: 10.1016/j.celrep.2018.01.023

Figure 6. Semi-specific Interactions with Glycan Shield Observed with Hotspot around Heavy Chain Position 5.

Figure 6

(A) Modeled glycan shield co-recognition of Arg hits identified by surface-matrix screening of 10E8 variants.

(B) Impact of Arg additions on the neutralization (and polyreactivity) of 10E8 variants.

(C) Average improvement in 10E8 variant neutralization upon the addition of 1 or 2 Arg. Error bars represent SD.

See also Figure S4 and Table S1D.