Table 2. The Relative Risk of Preelampsia for Women with Untreated Depression, Depression and Receiving Psychotherapy, Antidepressant Exposure and No Depression, Antidepressant Exposure and Depression, and Timing of Antidepressant Exposure, Among 21,589 pregnant womem in Kaiser Permanente Northern California, between 2010 and 2012.

	Total n	Preeclampsia n (%)	cRRa	95%CI	aRRb,c	95%CI	cRR	95%CI	aRRc	95%CI	cRR	95%CI	aRRc	95%CI
Antidepressant exposure and depression	1732	120 (6.9)	1.62	1.33 - 1.98	1.37	1.06-1.76	1.71	1.24 - 2.37	1.29	0.87 - 1.92	1.68	1.26 - 2.25	1.63	1.17-2.28
First trimester user only	580	25 (4.3)	0.98	0.65 - 1.48	0.76	0.49-1.19	1.04	0.64 - 1.68	0.74	0.43 - 1.27	1.02	0.65 - 1.61	0.94	0.57-1.54
Second trimester user ever	1152	95 (8.2)	1.96	1.57 - 2.45	1.7	1.30-2.23	2.07	1.47 - 2.91	1.6	1.06-2.41	2.03	1.50 - 2.76	2.05	1.44-2.91
Antidepressant exposure and no depression	149	4 (2.7)	0.6	0.22 - 1.63	0.53	0.19 - 1.44	0.64	0.23 - 1.78	0.49	0.17-1.42	0.62	0.23 - 1.73	0.61	0.22-1.71
First trimester user only	91	0 (0)	-	-	-	-	-	-	-	-	-	-	-	-
Second trimester user ever	58	4 (6.9)	1.62	0.58 - 4.47	1.34	0.48-3.79	1.71	0.60 - 4.87	1.29	0.44-3.79	1.68	0.59 - 4.74	1.56	0.54-4.55
Depression and psychotherapy	1961	83 (4.2)	0.96	0.76 - 1.22	0.8	0.61-1.04	1.02	0.72 - 1.44	0.83	0.57 - 1.22	ref	ref	ref	ref
Untreated depression	1345	56 (4.2)	0.95	0.72 - 1.25	0.95	0.71 - 1.27	ref	ref	ref	ref
No depression	16402	719 (4.4)	ref	ref	ref	ref

^acRR = crude Relative Risk

^baRR = adjusted Relative Risk

^cadjusted for Pre-pregnancy BMI, maternal age, race/ethnicity, marital status, parity, alcohol use, smoking, diabetes, other indications for antidepressant medications, other mental health diagnoses