Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 16;7(4):e1414119. doi: 10.1080/2162402X.2017.1414119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Radiotherapy and L19-IL2 induced abscopal effects and immune infiltration. (A) Experimental setup and schedule used for abscopal study. Each mouse was injected with tumour cells on the left flank on day −10 and on the right flank on day −8. (B) The fraction of non-irradiated tumours not reaching 4 times start tumour volume. n = number of non-irradiated tumours (one per mouse). Treatment of mice with 15Gy + vehicle, 15Gy + L19-IL2, 5 × 2Gy + vehicle and 5 × 2Gy + L19-IL2 was performed in one single experiment (27 mice in total) and treatment with 5 × 5Gy + L19-IL2 was performed in an additional experiment (n = 6). (C) Representative back gating (red), FACS image showing intratumoural CD3⁺CD4⁺ cells of gated CD45⁺ cells of irradiated (L) and non-irradiated (R) tumours, a quantification of the intratumoural CD3⁺CD4⁺ and CD3⁺CD8⁺ cells and the experimental schedule used. *p < 0.05. Bars represent median.