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. 2018 Jan 16;7(4):e1414119. doi: 10.1080/2162402X.2017.1414119

Figure 2.

Figure 2.

The abscopal effect in T cells depleted and mismatched tumour-bearing mice. Each mouse was injected with one tumour on the left flank on day −10 and with one tumour on the contralateral flank on day −8. (A) Depletion study schedule and FACS to confirm depletion of CD4+ or CD8+ T cells in blood. (B) Fraction of tumours not reaching 4 times start tumour volume. n = number of non-irradiated tumours. This depletion study was performed once, using 20 mice in total. (C) Experimental setup and schedule used for abscopal study using mismatched (CT26) secondary tumours. (D) Fraction of tumours not reaching 4 times start tumour volume for the different treatment groups. n = number of non-irradiated tumours. For C51 (matched) tumours, we used the same groups as described in Fig. 1 to compare them with the mismatched tumours.