Table 3.
Statistical tests comparing the effect of stimulation on eye and finger velocity and error during the execution phase of the sequential reaching task
| DBS Condition | Latency Estimated Mean ± SE (s) | Velocity Estimated Mean ± SE (m/s) | Error1 Estimated Mean ± SE (m) | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Eye | Finger | Eye | Finger | Eye | Finger | |
| DBS-OFF | 0.358 ± 0.03 | 0.630 ± 0.07 | 0.659 ± 0.08 | 0.237 ± 0.02 | 0.036 ± 0.002 | 0.043 ± 0.004 |
| DBS-LEFT | 0.402 ± 0.03 | 0.627 ± 0.07 | 0.746 ± 0.08 | 0.29 3 ± 0.02 | 0.038 ± 0.002 | 0.046 ± 0.004 |
| DBS-RIGHT | 0.41 0 ± 0.03 | 0.69 0 ± 0.07 | 0.727 ± 0.08 | 0.227 ± 0.02 | 0.038 ± 0.002 | 0.04 5 ± 0.004 |
| DBS-BL | 0.385 ± 0.03 | 0.636 ± 0.07 | 0.885 ± 0.08 | 0.287 ± 0.02 | 0.037 ± 0.002 | 0.049 ± 0.004 |
| Omnibus Test | F3,879 = 3.87 p = 0.009* |
F3,885 = 4.57 p = 0.004* |
F3,2663 = 37.2 | F3,2681 = 141.72 p < 0.001* p < 0.001* |
F3,2662 = 1.01 p = 0.389 |
F3,2680 = 12.07 p < 0.001* |
| Pairwise comparisons2 | ||||||
| Off - Left | Diff = −0.04 t = −2.62 p = 0.054 |
Diff = 0 .002 t = 0.12 p = 1 |
Diff = −0.09 t = −4.03 p < 0.001* |
Diff = −0.06 t = −13.87 p < 0.001* |
Diff = −0 .001 t = −1.04 p = 1 |
Diff = −0 .003 t = −3.04 p = 0.014* |
| Off - Right | Diff = −0.05 t = −3.17 p = 0.009* |
Diff = −0.06 t = −3.06 p = 0.014* |
Diff = −0.07 t = −3.19 p = 0.009* |
Diff = 0.01 t = 2.47 p = 0.08 |
Diff = −0 .002 t = −1.66 p = 0.58 |
Diff = −0 .002 t = −1.7 p = 0.53 |
| Off - BL | Diff = - 0.03 t = −1.59 p = 0.678 |
Diff = −0.01 t = −0.32 p = 1 |
Diff = −0.23 t = −10.32 p < 0.001* |
Diff = −0.05 t = −12.37 p < 0.001* |
Diff = −0 .001 t = −0.52 p = 1 |
Diff = −0.0 06 t = −5.88 p < 0.001* |
| Left – Right | Diff = −0.01 t = −0.51 p = 1 |
Diff = −0.06 t = −3.16 p = 0.01* |
Diff = 0.02 t = 0.9 p = 1 |
Diff = 0.07 t = 16.49 p < 0.001* |
Diff = −0 .001 t = −0.6 p = 1 |
Diff = 0 .001 t = 1.42 p = 0.94 |
| Left - BL | Diff = 0.02 t = 1 p = 1 |
Diff = −0.01 t = −0.43 p = 1 |
Diff = −0.14 t = −6.31 p < 0.001* |
Diff = 0.01 t = 1.47 p = 0.85 |
Diff = 0 .001 t = 0.5 p = 1 |
Diff = −0 .003 t = −2.89 p = 0.02* |
| Right - BL | Diff = 0.03 t = 1.51 p = 0.782 |
Diff = 0.05 t = 2.71 p = 0.041* |
Diff = −0.16 t = −7.27 p < 0.001* |
Diff = −0.06 t = −14.95 p < 0.001* |
Diff = 0 .001 t = 1.09 p = 1 |
Diff = −0 .004 t = −4.24 p < 0.001* |
DBS, Deep Brain Stimulation; SE, Standard Error; s, seconds; m/s, meters/second; m, meters; BL, Bilateral; Diff, Difference
1
estimated means are adjusted for peak velocity
2
p-values are adjusted for multiple comparisons using the Bonferroni method
*
denotes statistical significance