Figure 6. Circulating aggregated amylin triggers systemic inflammation in male AKO mice.

ELISA data showing the average levels of IL-1β in plasma from male and female AKO mice infused with either aggregated human amylin (h-Amy) or rat amylin (r-Amy). Measurements were done in 9 males and 5 females for both h-Amy and r-Amy. Plasma from WT littermate mice (n=4 males and n=4 females) was used as control. *P<0.05 using One-sample t-test to compare the mean to zero).