Table 1. Genomic and pathologic details of tumors harboring BRAF internal deletions.
Disease Ontology | N-Ras Mutations | K-Ras Mutations | B-Raf Mutations | BRAF Exons Deleted |
---|---|---|---|---|
unknown primary melanoma | ND | ND | V600 K601>E | 2-8 |
unknown primary melanoma | ND | ND | V600E | 4-8 |
unknown primary melanoma | ND | ND | V600K | 2-10 |
unknown primary melanoma | ND | ND | ND | 2-10 |
unknown primary melanoma | ND | ND | V600E | 3-10 |
skin melanoma | ND | ND | V600E | 2-8 |
skin melanoma | ND | ND | T599I | 3-8 |
skin melanoma | ND | ND | V600E | 2-8 |
head and neck melanoma | ND | ND | L597S | 2-8 |
vulva melanoma | ND | ND | D594G | 3-8 |
bladder urothelial (transitional cell) carcinoma | ND | ND | D587H | 3-8 |
bone marrow multiple myeloma | ND | ND | V600E | 2-8 |
bone marrow multiple myeloma | ND | ND | V600E | 2-8 |
bone marrow multiple myeloma | ND | ND | ND | 2-10 |
brain glioblastoma | ND | ND | ND | 3-8 |
breast carcinoma (nos) | ND | ND | ND | 4-7 |
breast invasive ductal carcinoma | ND | ND | ND | 5-9 |
lung adenocarcinoma | ND | G12C | ND | 2-9 |
lung non-small cell lung carcinoma | ND | ND | D594G | 4-8 |
lung non-small cell lung carcinoma | ND | ND | G464A | 4-8 |
nasopharynx and paranasal sinuses carcinoma | ND | ND | L485F | 3-8 |
pancreas ductal adenocarcinoma | ND | ND | S467L | 2-10 |
prostate acinar adenocarcinoma | ND | ND | ND | 4-8 |
thymus thymoma | ND | ND | ND | 3-10 |
unknown primary adenocarcinoma | ND | ND | ND | 2-7 |
unknown primary germ cell tumor | ND | amplification | ND | 3-8 |
ND: Not detected. NOS: Not otherwise specified