Bladder weights and smooth muscle hypertrophy are increased in BOO and this increase is blocked by glyburide (Gly) and anakinra (Ana). A. Bladder weights of the various experimental conditions are shown. Data are presented as mean ± SEM. n = 4 for Control, 6 for Sham, 6 for BOO + Veh, 5 for BOO + Gly, 4 for BOO + Ana. * indicates P<0.05, ** indicates P<0.01 for the comparisons indicated. Any between-group comparisons that are not indicated were not significant. B. Mason’s trichrome staining of tissue sections from the various groups indicated in B.