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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Biol Psychiatry. 2017 Oct 6;84(2):85–94. doi: 10.1016/j.biopsych.2017.09.024

Figure 1.

Figure 1

Corticosterone acts in the prelimbic cortex to potentiate reinstatement of cocaine seeking. A) Electric footshock stress (SHOCK; n=6) potentiates reinstatement when given in combination with a low dose of cocaine (COC; 2.5 mg/kg, i.p). B) Systemic corticosterone (CORT; 2 mg/kg, i.p.; n=5) reproduces the effect of footshock and potentiates reinstatement when given 40 minutes prior to an injection of low dose cocaine (2.5 mg/kg, i.p). C) 2-hydroxypropyl-β-cyclodextrin HBC-conjugated corticosterone (CORT; 50 ng/0.3 μL; n=7) administered directly into the prelimbic cortex (PL) 10 minutes prior to a low dose cocaine injection (2.5 mg/kg, i.p) induces significant reinstatement whereas either administered alone does not (p<.05; **p<.01, *p<.05, compared to extinction). Data are presented as mean ± SEM.