Fig. 3.

Pulmonary inflammation 3 h and 1 day after fracture (Fx) and combined fracture and thoracic trauma (Fx + TxT) in vehicle-, anti-IL-6 antibody-, and sgp130Fc-treated mice. a Representative images of hematoxylin and eosin (H&E) stained lungs of vehicle-treated mice after 3 h and b 1 day. c Representative images of lungs stained for neutrophils (Ly-6G+); arrowheads indicate positively stained cells. d Neutrophil (Ly-6G+) number in lung tissue. e IL-6 and f CXCL1 chemokine (C-X-C motif) ligand 1 concentrations in the broncho-alveolar lavage fluid after 3 h. Data are displayed as means ± standard deviation. D n = 5–6; E, F n = 8–9. *p ≤ 0.05; **p ≤ 0.01. Data of untreated animals are presented in Supplemental Table 1