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. 2017 Dec 28;5(12):e1595. doi: 10.1097/GOX.0000000000001595

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Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Fig. 3. — H&E histology and mixed chimerism. A–C, Graft and host tissue components in a syngeneic transplant combination (>130 d): syngeneic (B6) graft heart (*), cross-section including both ventricles, with associated body wall, including sternum with cellular hematopoietic bone marrow (***), attached muscles have (expected) myofiber loss (atrophy), and scattered mineralized fibers (A); host B6 heart (*) longitudinal (sagittal) section including right and left ventricles (B); graft heart base (rostral to A) polyethylene cuff tube- (yellow (*)), graft thymus (**) with distinct medulla and cortex (C), attached sternum (***) and musculature. (D–F) Graft (BALB/c) heart and host (B6) tissue components in an allogeneic CoB-treated transplant combination (>130 d): graft (BALB/c) heart with great vessels and cuff, attached graft sternum (****) and ribs (***) with hematopoietic bone marrow, graft thymus with distinct medulla and cortex (D); graft sternum bone marrow (E) and host sternum bone marrow (F); active hematopoiesis in both indicates viability of the VBM component. (G) Donor-specific chimerism is observed in peripheral blood mononuclear cells (>130 d) of C57BL6 recipients of a Balb/c allograft treated with CoB indicating viability of the VBM component of the chest wall allograft (data obtained from 2 to 3 animals).