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. 2018 Apr 6;5(2):ENEURO.0080-18.2018. doi: 10.1523/ENEURO.0080-18.2018

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Copyright © 2018 Baker et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 9. — Effects of NK1 receptor antagonist on Ca²⁺ transient responses to EFS. A, B, Representative ST maps showing the inhibitory effects of NK1 antagonist, RP 67580 (1 μM), on Ca²⁺ transients in response to nerve stimulation (EFS at 10 Hz for 5 s; indicated by the red line and dotted white box in ST maps). C–F, Summary data showing the inhibitory effects of RP 67580 (1 μM) on Ca²⁺ transient frequency (C), amplitude (D), duration (E), and spatial spread (F) in ICC-DMP during the control period, during the final 3 s of EFS, and during the post-EFS period (5 s), n = 4, c = 11. Note: RP 67580 reduced all Ca²⁺ transient parameters significantly; ns = p > 0.05, *p < 0.05, **p < 0.01.