Table 3.
Subgroup analysis of the associations between change in fasting glucose and the risk of stroke
| Fasting glucose level at baseline (mg/dL) | NFG (< 100.0 mg/dL) | IFG (100.0–125.9 mg/dL) | ||||
|---|---|---|---|---|---|---|
| Fasting glucose level after 2-year (mg/dL) | NFG (< 100.0 mg/dL) | IFG (100.0–125.9 mg/dL) | DFG (≥ 126.0 mg/dL) | NFG (< 100.0 mg/dL) | IFG (100.0–125.9 mg/dL) | DFG (≥ 126.0 mg/dL) |
| Age < 65 years | ||||||
| Subtotal (N) | 136,764 | 32,057 | 3188 | 28,272 | 19,977 | 3615 |
| Number of cases (n) | 2687 | 747 | 95 | 703 | 518 | 107 |
| HR (95% CI) | 1 | 1.06 (0.97–1.15) | 1.19 (0.97–1.47) | 1.03 (0.91–1.15) | 1 | 1.01 (0.82–1.24) |
| Age ≥ 65 years | ||||||
| Subtotal (N) | 19,957 | 5765 | 829 | 5335 | 3879 | 849 |
| Number of cases (n) | 1726 | 527 | 87 | 479 | 366 | 102 |
| HR (95% CI) | 1 | 1.04 (0.95–1.15) | 1.20 (0.97–1.50) | 0.99 (0.87–1.14) | 1 | 1.22 (0.98–1.53) |
| Men | ||||||
| Subtotal (N) | 83,348 | 23,763 | 2790 | 20,418 | 16,354 | 3240 |
| Number of cases (n) | 2416 | 790 | 117 | 717 | 599 | 149 |
| HR (95% CI) | 1 | 1.05 (0.97–1.14) | 1.16 (0.96–1.40) | 1.00 (0.90–1.12) | 1 | 1.08 (0.90–1.30) |
| Women | ||||||
| Subtotal (N) | 73,373 | 14,059 | 1227 | 13,189 | 7502 | 1224 |
| Number of cases (n) | 1997 | 484 | 65 | 465 | 285 | 60 |
| HR (95% CI) | 1 | 1.03 (0.94–1.14) | 1.25 (0.97–1.60) | 1.03 (0.89–1.20) | 1 | 1.08 (0.82–1.43) |
| BMI < 25.0 kg/m2 | ||||||
| Subtotal (N) | 111,438 | 24,195 | 2411 | 22,436 | 14,195 | 2368 |
| Number of cases (n) | 3030 | 819 | 113 | 756 | 534 | 114 |
| HR (95% CI) | 1 | 1.06 (0.98–1.15) | 1.18 (0.97–1.42) | 0.97 (0.87–1.09) | 1 | 1.07 (0.88–1.32) |
| BMI ≥ 25.0 kg/m2 | ||||||
| Subtotal (N) | 45,255 | 13,615 | 1605 | 11,157 | 9651 | 2095 |
| Number of cases (n) | 1383 | 455 | 69 | 426 | 349 | 95 |
| HR (95% CI) | 1 | 1.00 (0.90–1.12) | 1.20 (0.94–1.53) | 1.09 (0.94–1.26) | 1 | 1.12 (0.89–1.41) |
Hazard ratio analyzed by Cox proportional hazards regression analysis adjusted for age, sex, socioeconomic status, physical activity, smoking status, alcohol consumption, body mass index, blood pressure, total cholesterol, Charlson comorbidity index, and baseline fasting glucose level
n number, HR hazard ratio, CI confidential interval, NFG normal fasting glucose (< 100.0 mg/dL), IFG impaired fasting glucose (100.0–125.9 mg/dL), DFG diabetic fasting glucose (≥ 126.0 mg/dL)