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. 2018 Apr 6;16:13. doi: 10.1186/s12964-018-0225-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Changes in the lung nodules and the expression of IL-8 and phosphorylated FAK in pulmonary metastatic lesions. a The group given nIL-8 Ab showed a significant suppression of the size of the pulmonary metastatic lesion. (*) p < 0.05. b Immunostaining of the tissues collected from the pulmonary metastatic lesion. Decreased expression of IL-8 and phosphorylation of FAK was observed in the group administered nIL-8 Ab. Original magnification, × 400; Scale bars: 50 μm. c The number of IL-8 and p-FAK positive cells per unit area. Data represents represent the mean ± SD of three independent experiments. p < 0.05 was considered to indicate significance: (*) p < 0.05, (**) p < 0.01