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The experimental scheme for the antagonistic effects of PK11195 against the analgesic effects of koumine.
| Group | CCI | Catheterization | s.c. | Intrathecal (PK) |
|---|---|---|---|---|
| Sham 1 | − | − | NS | — |
| Sham 2 | − | + | NS | Vehicle |
| CCI + NS | + | + | NS | Vehicle |
| CCI + KM | + | + | KM | Vehicle |
| CCI + PK | + | + | NS | PK (1 μg/10 μl) |
| CCI + KM + PK (0.04 μg) | + | + | KM | PK (0.04 μg/10 μl) |
| CCI + KM + PK (0.2 μg) | + | + | KM | PK (0.2 μg/10 μl) |
| CCI + KM + PK (1 μg) | + | + | KM | PK (1 μg/10 μl) |
KM: koumine; PK: PK11195; NS: normal saline.
