Table 4.
The association of SNPs with CAD risk in additive inheritance mode.
| Gene | SNPs genotype | CAD positive n (%) | CAD negative n (%) | OR (95% CI) | p | OR′ (95% CI′) | p′ |
|---|---|---|---|---|---|---|---|
| GIP | rs2291725 | ||||||
| C/C | 187 (48.6) | 102 (37.5) | |||||
| C/T | 152 (39.5) | 140 (51.5) | 0.592 (0.424–0.826) | 0.002 | 0.603 (0.392–0.930) | 0.022 | |
| T/T | 46 (11.9) | 30 (11.0) | 0.836 (0.498–1.406) | 0.500 | 0.709 (0.502–1.001) | 0.051 | |
| rs8078510 | |||||||
| G/G | 281 (73.2) | 174 (64.7) | |||||
| G/A | 96 (25.0) | 90 (33.5) | 0.660 (0.468–0.932) | 0.018 | 0.567 (0.364–0.883) | 0.012 | |
| A/A | 7 (1.8) | 5 (1.8) | 0.867 (0.271–2.774) | 0.810 | 1.065 (0.427–2.653) | 0.893 |
OR′, 95% CI′, and p′ were calculated by logistic regression analysis after adjustment for other known CAD risk factors (age, BMI, smoking status, dyslipidemia history, hypertension history, and diabetic duration).